From Greenville and points south (Columbia, SC; Jacksonville, FL) via I-26:
Exit I-26 at the first exit in North Carolina (Exit 67). Turn right on 108 and go 5 miles through the little town of Columbus to Highway 9. Turn left (north) toward Lake Lure. Go 7 miles to Grassy Knob Road on the right. Go 4 miles on Grassy Knob Road to Serenity Farm on the right.
A phone call to the Stricklands (828 625-1122) will assure you that someone can meet you and show you the Preserve.